The Filing Desk

Cytokinetics vs Repligen

Cytokinetics CYTK · Repligen RGEN · Biotechnology

Repligen reported revenue of $738 million in fiscal 2025, 8.4 times Cytokinetics' $88 million in fiscal 2025. Cytokinetics' revenue grew 376.6% in its latest year, and Repligen's grew 16.4%. Cytokinetics had an operating margin of -695.4%, against 7.5% at Repligen. Free cash flow was −$535 million at Cytokinetics and $94 million at Repligen.

Side by side

CytokineticsRepligen
Latest fiscal yearFY2025, Dec 31, 2025FY2025, Dec 31, 2025
Revenue$88M$738M
Revenue growth376.6%16.4%
Revenue growth a year, last 5 years9.5%15.0%
Gross margin—52.3%
Operating margin−695.4%7.5%
Net margin−891.6%6.6%
Free cash flow−$535M$94M
Free cash flow margin−607.5%12.7%
Return on capital—2.4%
Net debt to EBITDA—−1.7x
Dividends and buybacks$0M$0M
Change in diluted share count——
Last close$60.73$180.17
P/E at the last close——
Insider trades, last 12 monthssold $51.4 millionsold $14.2 million
Piotroski F-score——
Amounts in each company's own currency, US$ unless marked (a foreign company may report in another), each company's latest fiscal year from its 10-K, or 20-F or 40-F for a foreign company. Growth rates compare with the year before; the five-year rate is the average a year. Free cash flow is cash from operations minus capital spending; return on capital is after-tax operating income over the money invested in the business; P/E is the last close over the latest earnings per share. Banks are measured differently (return on equity, efficiency ratio), so some rows apply to one company only.

Ten years

Revenue
US$ billions, fiscal years
CytokineticsRepligen
Operating margin
Percent of revenue
CytokineticsRepligen
Free cash flow
US$ billions. Cash from operations minus capital expenditure.
CytokineticsRepligen

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Source: the companies' Form 10-K filings, from SEC EDGAR, and the last close. For information only, not investment advice: the figures describe results, not which company is the better investment. The Filing Desk is not affiliated with either company. Full figures on the Cytokinetics and Repligen pages.