The Filing Desk

Moderna vs Sarepta Therapeutics

Moderna MRNA · Sarepta Therapeutics SRPT · Biotechnology

Sarepta Therapeutics reported revenue of $2.2 billion in fiscal 2025, about the same as Moderna's $1.9 billion in fiscal 2025. Moderna's revenue fell 39.9% in its latest year, and Sarepta Therapeutics' grew 15.6%. Moderna had an operating margin of -158.1%, against -31.8% at Sarepta Therapeutics. Free cash flow was −$2.1 billion at Moderna and −$307 million at Sarepta Therapeutics.

Side by side

ModernaSarepta Therapeutics
Latest fiscal yearFY2025, Dec 31, 2025FY2025, Dec 31, 2025
Revenue$1.9B$2.2B
Revenue growth−39.9%15.6%
Revenue growth a year, last 5 years19.3%32.4%
Gross margin55.4%98.8%
Operating margin−158.1%−31.8%
Net margin−145.2%−32.5%
Free cash flow−$2.1B−$307M
Free cash flow margin−106.2%−14.0%
Return on capital−65.4%−47.2%
Net debt to EBITDA——
Dividends and buybacks$2M$25M
Change in diluted share count1.3%−7.2%
Last close$254.19$17.82
P/E at the last close——
Insider trades, last 12 monthssold $81.6 millionsold $417,410
Piotroski F-score2 of 93 of 8
Amounts in each company's own currency, US$ unless marked (a foreign company may report in another), each company's latest fiscal year from its 10-K, or 20-F or 40-F for a foreign company. Growth rates compare with the year before; the five-year rate is the average a year. Free cash flow is cash from operations minus capital spending; return on capital is after-tax operating income over the money invested in the business; P/E is the last close over the latest earnings per share. Banks are measured differently (return on equity, efficiency ratio), so some rows apply to one company only.

Ten years

Revenue
US$ billions, fiscal years
ModernaSarepta Therapeutics
Operating margin
Percent of revenue
ModernaSarepta Therapeutics
Free cash flow
US$ billions. Cash from operations minus capital expenditure.
ModernaSarepta Therapeutics

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Source: the companies' Form 10-K filings, from SEC EDGAR, and the last close. For information only, not investment advice: the figures describe results, not which company is the better investment. The Filing Desk is not affiliated with either company. Full figures on the Moderna and Sarepta Therapeutics pages.