PTC Therapeutics
PTC Therapeutics' revenue rose 114.5% to $1.7 billion in fiscal 2025. Its operating margin was 50.1%, up from −37.5% a year earlier. Free cash flow was $702 million. The diluted share count rose 14.9%.
PTC Therapeutics, Inc.
Latest fiscal year ended December 31, 2025
10-K filed February 19, 2026 · 0001104659-26-017575
Updated
Revenue
$1.7B
114.5%
Operating margin
50.1%
87.6 pts
Net income
$683M
Free cash flow
$702M
Return on equity
—
Market cap
$5.5B
Nov 6 close
P/E
—
Loss: no P/E
Operating margin is operating income as a share of revenue. Free cash flow is cash from operations minus capital spending. Return on equity is net income as a share of shareholders' equity. Market cap is the last closing share price times the latest diluted share count, so it is approximate. P/E is the last close divided by diluted earnings per share over the last four quarters, or the latest fiscal year where the quarters aren't available; there is none when the company made a loss.
About these figures. PTC Therapeutics' 2025 filing doesn't tag its total borrowings, which the Piotroski score needs to judge whether debt fell, so the score is blank for 2025.
Charts show fiscal years, from the 10-K filings.
Income statement
Revenue and net income
US$ billions, fiscal years; net losses in red. Revenue on the left axis, net income on the right; zero is the same line on both.
Revenue (left axis)Net income (right axis)
Gross profit, R&D and operating income
US$ billions, fiscal years. Gross profit is revenue minus the cost of what was sold; research and development is one of the costs paid from it; what remains after all operating costs is operating income. Losses in red.
Gross profitResearch and developmentOperating income
Margins
Percent of revenue
GrossOperatingNetFree cash flow
Diluted earnings per share
US$ per share, fiscal years, restated for any stock splits; loss years in red.
Returns on capital
Return on capital and on equity
Percent. Return on capital is after-tax operating income over the money invested in the business (debt plus equity, minus cash); return on equity is net income over shareholders' equity. Both use the average of opening and closing balances.
Return on capitalReturn on equity
Balance sheet
Cash and debt
US$ billions, at each fiscal year end. Debt includes finance leases.
Cash and short-term investmentsDebt
Assets, liabilities and equity
US$ billions, at each fiscal year end. Assets equal liabilities plus equity; negative equity in red.
Total assetsTotal liabilitiesShareholders' equity
Debt and liquidity ratios
Times. Debt to equity, current assets over current liabilities, and net debt over EBITDA (a full year's).
Debt to equityCurrent ratioNet debt to EBITDA
Five years at a glance
| Fiscal year end | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|
| Cash and short-term investments | 773 | 411 | 877 | 1,140 | 1,945 |
| Debt incl. finance leases | 454 | — | 304 | 304 | — |
| Net debt (negative means net cash) | −319 | — | −572 | −836 | — |
| Net debt to EBITDA | — | — | — | — | — |
| Debt to equity | — | — | — | — | — |
| Interest coverage | −39.0x | −24.2x | −12.2x | −52.0x | 152.0x |
| Current ratio | 1.9x | 1.7x | 2.0x | 2.4x | 2.4x |
| Quick ratio | 1.8x | 1.6x | 2.0x | 2.3x | 2.3x |
US$ millions unless stated, at each fiscal year end. Net debt to EBITDA is debt minus cash, divided by operating income before depreciation and amortization: roughly how many years of those earnings the net debt equals. Debt to equity is debt as a multiple of shareholders' equity. Interest coverage is operating income divided by interest expense. The current ratio is current assets over current liabilities; the quick ratio leaves out inventory.
Cash flow
Cash from operations, capital spending and free cash flow
US$ billions, fiscal years. Free cash flow is cash from operations minus capital spending; negative years in red.
Cash from operationsCapital spendingFree cash flow
Stock-based compensation and buybacks
US$ billions, fiscal years. Shares paid to employees (stock-based compensation, a cost that uses no cash) against cash spent buying shares back. Buybacks that only match it leave the share count roughly where it was.
Stock-based compensationShare buybacks
Dividends and buybacks
US$ billions, cash paid in each fiscal year
DividendsShare buybacks
Diluted share count
Weighted-average diluted shares, millions
Projections
Project PTC Therapeutics' revenue, net income and earnings per share five years ahead in a bull, a base and a bear case with your own figures, and see the share prices your P/E estimates give them, or value it with a discounted cash flow model. Every projected figure is yours: it is not a forecast of ours.
What PTC Therapeutics says to expect
- Full year 2026: total and product revenue
Expected total revenue increased to $1.29 to $1.32 billion, with total product revenue guidance raised to $960 to $990 million from $850 to $950 million
- Full year 2026: GAAP R&D and SG&A expense
GAAP R&D and SG&A expense guidance remains $775 to $815 million
- Full year 2026: non-GAAP R&D and SG&A expense
Non-GAAP R&D and SG&A expense guidance remains $680 to $720 million, excluding estimated non-cash, stock-based compensation expense of $95 million
The company's own words, from its earnings release (Form 8-K, Exhibit 99), filed October 29, 2026. They are its expectations, not ours, and not a forecast or price target from The Filing Desk. Replaced when the next release is out.
Insider trades
Over the 12 months between November 7, 2025 and November 6, 2026, no insider bought PTC Therapeutics shares on the open market, and 13 insiders sold $55.5 million, all of it under trading plans set up in advance.
Buys and sells by month
US$ millions, open-market purchases (up) and sales (down) by officers, directors and 10% owners in each month.
BoughtSold
| Date | Insider | Trade | Shares | Price | Value | Filing |
|---|---|---|---|---|---|---|
| Sep 17, 2026 | Michael SchmertzlerDirector | Sold plan | 10,000 | $67.85 | $678,533 | Form 4 |
| Sep 16, 2026 | Michael SchmertzlerDirector | Sold plan | 10,000 | $67.12 | $671,195 | Form 4 |
| Sep 10, 2026 | Michael SchmertzlerDirector | Sold plan | 10,000 | $67.34 | $673,400 | Form 4 |
| Sep 9, 2026 | Michael SchmertzlerDirector | Sold plan | 10,000 | $67.84 | $678,403 | Form 4 |
| Aug 27, 2026 | Michael SchmertzlerDirector | Sold plan | 12,500 | $71.58 | $894,784 | Form 4 |
| Aug 26, 2026 | Michael SchmertzlerDirector | Sold plan | 12,500 | $72.94 | $911,725 | Form 4 |
| Aug 20, 2026 | Michael SchmertzlerDirector | Sold plan | 12,500 | $71.11 | $888,858 | Form 4 |
| Aug 19, 2026 | Michael SchmertzlerDirector | Sold plan | 12,500 | $73.32 | $916,554 | Form 4 |
| Aug 17, 2026 | Mark Elliott BouldingExec. VP and CLO | Sold plan | 2,813 | $72.57 | $204,127 | Form 4 |
| Aug 4, 2026 | Matthew B. KleinChief Executive Officer, Director | Sold plan | 10,292 | $68.57 | $705,722 | Form 4 |
| Jul 14, 2026 | Pierre GravierChief Financial Officer | Sold plan | 3,494 | $80.35 | $280,743 | Form 4 |
| Jul 9, 2026 | Mary L. SmithDirector | Sold plan | 15,834 | $90.00 | $1.4 million | Form 4 |
The latest 12 of 82 trades. Open-market purchases and sales by officers, directors and 10% owners, from their Form 4 filings with the SEC: one row per person, day and filing, at the day's average price. Grants, option exercises and shares withheld for tax aren't counted. Insiders buy and sell for many reasons, such as taxes, spreading their savings or a plan set up months earlier, so a trade on its own says little about where a company is heading. For information only, not investment advice. Insider trades at all companies
Indicators
Four widely used measures, worked out from the company's filings. The cutoffs are the ones their authors or users go by, not a verdict of ours.
| Indicator | FY23 | FY24 | FY25 |
|---|---|---|---|
| Piotroski F-score | — | 3 of 8 | — |
| Rule of 40 | 14.3% | −28.1% | 155.1% |
| Altman Z'' | −5.39 | −5.56 | 1.56 |
| Accruals ratio | −26.0% | −14.2% | −1.2% |
Piotroski F-score: how many of nine simple tests of profitability, funding and efficiency the company passed in the year (Piotroski, 2000); 8 or 9 is strong, 0 to 2 weak. Rule of 40: revenue growth plus free cash flow margin; software investors treat 40% or more as the bar. Altman Z'': working capital, retained earnings, operating income and equity weighed against assets and liabilities (Altman, 1995); Altman puts above 2.6 in the safe zone and below 1.1 in the distress zone. Accruals ratio: net income minus cash from operations, over average total assets; lower means profit is backed by cash.
The nine F-score tests
| Test | FY23 | FY24 | FY25 |
|---|---|---|---|
| Net income is positive | Fail | Fail | Pass |
| Cash from operations is positive | Fail | Fail | Pass |
| Return on assets rose | Fail | Pass | Pass |
| Cash from operations exceeds net income | Pass | Pass | Pass |
| Debt fell relative to assets | — | Fail | — |
| Current ratio rose | Pass | Pass | Fail |
| Share count didn't rise | Fail | Fail | Fail |
| Gross margin rose | — | — | — |
| Revenue rose relative to assets | Pass | Fail | Pass |
| F-score | — | 3 of 8 | — |
Companies that report no gross profit are scored on the other eight.
Compare
Put PTC Therapeutics side by side with any other company we cover: revenue, growth, margins, cash flow and returns, with ten years of charts.
Similar companies
| Company | Year | Revenue growth | Operating margin | Free cash flow margin | Return on capital | Net debt to EBITDA | F-score | Compare |
|---|---|---|---|---|---|---|---|---|
| PTC Therapeutics | FY25 | 114.5% | 50.1% | 40.6% | — | — | — | |
| Phibro Animal Health | FY26 | 17.1% | 12.8% | 0.7% | — | — | — | Compare |
| Alkermes | FY25 | −5.2% | 17.2% | 32.5% | — | — | — | Compare |
| Indivior | FY25 | 4.3% | 21.1% | −7.5% | — | 0.5x | 4 | Compare |
| Prestige Consumer Healthcare | FY26 | −4.3% | 28.4% | 22.6% | 8.2% | 2.8x | 5 | Compare |
Each company's latest fiscal year. Fiscal years end in different months, so the periods don't line up exactly. Free cash flow margin is free cash flow as a share of revenue. Net debt to EBITDA is explained under the balance sheet, and the F-score under Indicators.
10 years of figures
| Fiscal year | FY16 | FY17 | FY18 | FY19 | FY20 | FY21 | FY22 | FY23 | FY24 | FY25 |
|---|---|---|---|---|---|---|---|---|---|---|
| Income statement | ||||||||||
| Revenue | 83 | 194 | 265 | 307 | 381 | 539 | 699 | 938 | 807 | 1,731 |
| Revenue growth | 125.0% | 135.0% | 36.2% | 16.0% | 24.0% | 41.5% | 29.8% | 34.2% | −14.0% | 114.5% |
| Gross profit | 83 | 190 | 252 | 295 | — | — | — | — | — | — |
| Research and development | 118 | 118 | 172 | 258 | 478 | 541 | 652 | 667 | 534 | 455 |
| Operating income | −132 | −64 | −116 | −241 | −432 | −374 | −447 | −440 | −303 | 867 |
| Net income | −142 | −79 | −128 | −252 | −438 | −524 | −559 | −627 | −363 | 683 |
| Diluted EPS (US$) | −4.17 | −2.02 | −2.75 | −4.27 | −6.64 | −7.43 | −7.79 | −8.37 | −4.73 | 7.78 |
| Diluted shares (millions) | 34 | 39 | 47 | 59 | 66 | 70 | 72 | 75 | 77 | 88 |
| Cash flow | ||||||||||
| Cash from operations | −104 | −10 | −28 | −99 | −194 | −251 | −357 | −158 | −108 | 711 |
| Capital expenditure | 2 | 3 | 7 | 14 | 18 | 28 | 32 | 28 | 6 | 9 |
| Free cash flow | −105 | −13 | −35 | −112 | −212 | −280 | −389 | −187 | −114 | 702 |
| Dividends paid | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Share buybacks | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Acquisitions | 0 | 0 | 49 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Stock-based compensation | 35 | 31 | 33 | 42 | 70 | 104 | 110 | 102 | 75 | 74 |
| Balance sheet at fiscal year end | ||||||||||
| Cash and short-term investments | 232 | 191 | 228 | 687 | 1,104 | 773 | 411 | 877 | 1,140 | 1,945 |
| Debt incl. finance leases | 98 | 145 | 153 | 314 | — | 454 | — | 304 | 304 | — |
| Total assets | 269 | 392 | 1,119 | 1,624 | 2,208 | 1,938 | 1,706 | 1,896 | 1,705 | 2,899 |
| Total liabilities | 150 | 235 | 768 | 1,030 | 1,726 | 1,937 | 2,053 | 2,714 | 2,803 | 3,104 |
| Shareholders' equity | 120 | 156 | 351 | 594 | 482 | 1 | −347 | −819 | −1,098 | −205 |
| Margins and ratios | ||||||||||
| Gross margin | 100.0% | 97.7% | 95.2% | 96.0% | — | — | — | — | — | — |
| Operating margin | −159.7% | −33.1% | −43.7% | −78.6% | −113.4% | −69.5% | −64.0% | −46.9% | −37.5% | 50.1% |
| Net margin | −171.8% | −40.6% | −48.4% | −82.0% | −115.1% | −97.3% | −80.0% | −66.8% | −45.0% | 39.4% |
| Free cash flow margin | −127.4% | −6.8% | −13.1% | −36.6% | −55.6% | −51.9% | −55.6% | −19.9% | −14.2% | 40.6% |
| Rule of 40 (growth + FCF margin) | −2.4% | 128.3% | 23.1% | −20.7% | −31.6% | −10.4% | −25.9% | 14.3% | −28.1% | 155.1% |
| Return on capital | — | −105.5% | −47.3% | −76.5% | — | — | — | — | — | — |
| Return on equity | −82.2% | −57.2% | −50.5% | −53.2% | −81.4% | −216.8% | — | — | — | — |
| Return on assets | −44.8% | −23.9% | −16.9% | −18.3% | −22.9% | −25.3% | −30.7% | −34.8% | −20.2% | 29.7% |
| Net debt to EBITDA | — | — | — | — | — | — | — | — | — | — |
US$ millions unless stated. Where a later 10-K restated a year, the latest filed figure is shown. Download all figures (CSV, US$ millions)
Source: PTC Therapeutics' Form 10-K filings, from SEC EDGAR. For information only, not investment advice. The Filing Desk is not affiliated with PTC Therapeutics.