The Filing Desk

Illumina vs Waters

Illumina ILMN · Waters WAT · Life Sciences Tools & Services

Illumina reported revenue of $4.3 billion in fiscal 2025, 1.4 times Waters' $3.2 billion in fiscal 2025. Illumina's revenue fell 0.7% in its latest year, and Waters' grew 7.0%. Illumina had an operating margin of 18.6%, against 25.4% at Waters. Free cash flow was $931 million at Illumina and $540 million at Waters. Their fiscal years end in different months (December 28 and December 31), so the periods don't line up exactly.

Side by side

IlluminaWaters
Latest fiscal yearFY2025, Dec 28, 2025FY2025, Dec 31, 2025
Revenue$4.3B$3.2B
Revenue growth−0.7%7.0%
Revenue growth a year, last 5 years6.0%6.0%
Gross margin66.1%59.3%
Operating margin18.6%25.4%
Net margin19.6%20.3%
Free cash flow$931M$540M
Free cash flow margin21.4%17.1%
Return on capital20.3%21.0%
Net debt to EBITDA0.3x0.8x
Dividends and buybacks$742M$15M
Change in diluted share count−1.9%0.3%
Last close$271.04$455.98
P/E at the last close50.6×—
Insider trades, last 12 monthsbought $84,627, sold $592.9 millionbought $451,070, sold $1.4 million
Piotroski F-score8 of 96 of 9
Amounts in each company's own currency, US$ unless marked (a foreign company may report in another), each company's latest fiscal year from its 10-K, or 20-F or 40-F for a foreign company. Growth rates compare with the year before; the five-year rate is the average a year. Free cash flow is cash from operations minus capital spending; return on capital is after-tax operating income over the money invested in the business; P/E is the last close over the latest earnings per share. Banks are measured differently (return on equity, efficiency ratio), so some rows apply to one company only.

Ten years

Revenue
US$ billions, fiscal years
IlluminaWaters
Operating margin
Percent of revenue
IlluminaWaters
Free cash flow
US$ billions. Cash from operations minus capital expenditure.
IlluminaWaters

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Source: the companies' Form 10-K filings, from SEC EDGAR, and the last close. For information only, not investment advice: the figures describe results, not which company is the better investment. The Filing Desk is not affiliated with either company. Full figures on the Illumina and Waters pages.