The Filing Desk

AstraZeneca vs Merck

AstraZeneca AZN · Merck MRK · Pharmaceuticals

Merck reported revenue of $65.0 billion in fiscal 2025, about the same as AstraZeneca's $58.7 billion in fiscal 2025. AstraZeneca's revenue grew 8.6% in its latest year, and Merck's grew 1.3%. Free cash flow was $11.8 billion at AstraZeneca and $12.4 billion at Merck.

Side by side

AstraZenecaMerck
Latest fiscal yearFY2025, Dec 31, 2025FY2025, Dec 31, 2025
Revenue$58.7B$65.0B
Revenue growth8.6%1.3%
Revenue growth a year, last 5 years17.2%9.4%
Gross margin81.9%74.8%
Operating margin23.4%—
Net margin17.4%28.1%
Free cash flow$11.8B$12.4B
Free cash flow margin20.0%19.0%
Return on capital16.8%24.8%
Net debt to EBITDA—1.2x
Dividends and buybacks$5.5B$13.3B
Change in diluted share count−0.1%−1.3%
Last close$172.06$140.61
P/E at the last close—111.6×
Insider trades, last 12 monthsbought $3,248, sold $2.2 millionsold $72.0 million
Piotroski F-score9 of 94 of 9
Amounts in each company's own currency, US$ unless marked (a foreign company may report in another), each company's latest fiscal year from its 10-K, or 20-F or 40-F for a foreign company. Growth rates compare with the year before; the five-year rate is the average a year. Free cash flow is cash from operations minus capital spending; return on capital is after-tax operating income over the money invested in the business; P/E is the last close over the latest earnings per share. Banks are measured differently (return on equity, efficiency ratio), so some rows apply to one company only.

Ten years

Revenue
US$ billions, fiscal years
AstraZenecaMerck
Operating margin
Percent of revenue
AstraZenecaMerck
Free cash flow
US$ billions. Cash from operations minus capital expenditure.
AstraZenecaMerck

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Source: the companies' Form 10-K filings, from SEC EDGAR, and the last close. For information only, not investment advice: the figures describe results, not which company is the better investment. The Filing Desk is not affiliated with either company. Full figures on the AstraZeneca and Merck pages.